| 초록 |
We synthesized biodegradable and hydrophilic polyurethane (PU) dispersion by a prepolymer method. Dimethylol propionic acid, which served as the polyol, provides carboxyl groups in PU and improves the hydrophilicity of the PU film. The carboxyl groups of the PU were utilized for the conjugation with alendronate (Alen) and the ionic cross-linking among PU polymers. Alen conjugation and ionic cross-linking both significantly reduced the water contact angle. The Alen-conjugated PU (Alen-PU) film showed a ductile property with high elongation at break. The ionic cross-linking of Alen-PU film resulted in the improvement of Young's moduli and tensile strength. In addition, the biodegradation time of the PU-based films was increased due to the ionic cross-linking. The effect of Alen in PU film reduced proliferation and enhanced differentiation of pre-osteoblasts. We believed that the Alen-PU films have wide application potential in tissue engineering, especially for guided bone regeneration. |
