| 초록 |
Luteolin (3',4',5,7-tetrahydroxyflavone) has been of great interest due to its anti-oxidative, anti-inflammatory, and anti-carcinogenic effects. Despite these beneficial biological properties, the ease with which luteolin forms molecular crystals in conventional aqueous formulations has hampered much wider applications. Here, we introduce an oil-in-water (O/W) nanoemulsion vehicle system for enhanced cutaneous delivery of luteolin. The luteolin-loaded nanoemulsion, was produced by the assembly of poly(ethylene oxide)-block-poly(ε-caprolactone) and lecithin at the O/W interface. The luteolin-loaded nanoemulsion showed outstanding stability against drop coalescence and aggregation. Moreover, in vivo hair growth evaluation demonstrated that the luteolin-loaded nanoemulsions fabricated in this study possessed remarkable hair growth-promotion activity, which is comparable with the case of using a luteolin solution in an organic solvent. |
