| 초록 |
Cell-penetrating peptides (CPPs) are short cationic peptides that are able to traverse the plasma membranes. These peptides have been found to transport various cargo molecules inside the living cells, and thus are considered promising devices in clinical and biotechnological applications. While successful intracellular delivery of many bioactive compounds has been achieved using CPPs, their internalization mechanisms are still under investigation. In this work, we studied the action of the CPPs on free-standing planar model lipid membrane. By using mixtures of zwitterionic lipid (PC), anionic lipid (PG) and cholesterol, interactions between peptide and each membrane components were explored, focusing on the phase behavior induced by the interactions. |
