초록 |
Natural polymer, glucomannan has been employed as a multi-functional biomaterial, such as reducing type 2 diabetes beyond as food. However, despite its biocompatability, utilization as a biomaterial or bio-ink for 3D printing has been limited, because swelling and high viscosity was problem to fabricate. To solve above problems, we designed glucomannan controlling using tannic acid. Aggregates formed immediately at the interface was confirmed that the volume decreased by dehydration during the agglomeration process. By elucidating hydrogen bonding, formulations such as particles, membranes, and strings was available. In addition, this formation was confirmed to have the property of forming and breaking. Thus, using this hydrogen bonding controlling of glucomannan, efficient intestinal delivery of glucomannan and dissociation driven by bicarbonate secreted in the colon was possible. This hydration controlling by tannic acid could be taken advantage of drug delivery and 3D bio-printing. |