| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycidol for pH-Responsive Drug Delivery |
| 초록 |
We report the synthesis of well-defined hyperbranched double hydrophilic block copolymer of poly(ethylene oxide)-hyperbranched-polyglycidols (PEO-hb-PGLY) for an efficient drug delivery system. We demonstrate PEO-hb-PGLY can form a self-assembled micellar structure upon conjugation with hydrophobic therapeutics, doxorubicin, which is linked by pH-sensitive hydrazone bonds. Dynamic light scattering and transmission electron microscopy demonstrated the formation of the spherical core-shell type micelles. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, drug loading efficiency and improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform for excellent drug delivery systems. |
| 저자 |
이수은1, Kyohei Saito2, 이혜라3, 이민재3, Yuji Shibasaki2, Yoshiyuki Oishi2, 김병수1
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| 소속 |
1울산과학기술대, 2Iwate Univ., 3경희대 |
| 키워드 |
Drug delivery; double hydrophilic block copolymer; pH-responsive drug delivery; polyglycidol;
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| E-Mail |
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