| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effects of Molecular weights of PLGA on Release Behavior of Doxorubicin for Double-layered PLGA Microspheres |
| 초록 |
Doxorubicin acts as an anticancer agent that is rapidly distributed in humans and is accumulated in irrigated tissues such as liver, lung, kidney, etc. and especially heart. Double-layered microspheres fabricated relatively simple oil-in-water (O/W) solvent evaporation method and recognized the release behavior according to PLGA molecular weight and concentration and initial drug loading. Double-layered microspheres showed smooth surfaces and clear difference between inner-shell and outer-shell. In addition, the trend of wall-thickness change given by different PLGA molecular weight and concentration changed. The in vitro drug release profile showed a sustained release up to 35 days. According to PLGA molecular weight increased, the release rate of doxorubicin loaded double-layered microspheres decreased. These results showed that the variations of concentration and molecular weights of PLGA can be controlled the release behaviors. |
| 저자 |
박정수1, 이준희2, 박종학3, 안식일1, 이해방2, 강길선3
|
| 소속 |
1BK21 Polymer BIN Fusion Res. Team, 2Chonbuk Nat’l Univ., 3Korea |
| 키워드 |
Doxorubicin; PLGA; Microsphere; Double-layer
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| E-Mail |
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