| 초록 |
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) showing potent anti-inflammatory, analgesic and anti-pyretic activities. However, it has several side effects such as acute kidney failure, bone marrow depression, and liver damage. Towards the discovery of novel NSAID, which are expected to have improved drug efficacy and better toxicity profile than diclofenac, we have synthesized new derivatives of diclofenac phosphonates and carboxylic acid efficiently from commercially available 2-aminobenzyl alcohol using click chemistry and Arbuzov reaction in good yields. These synthetic compounds are tested for in vitro anti-inflammatory and antiviral activities and showed promising results that allowing us to pursue further studies. |
