| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | pH-sensitive photodynamic therapy agent for effective cancer therapy |
| 초록 | Photodynamic Therapy (PDT) could bring advantages for cancer therapy of various diseases. Under the laser irradiation, photosensitizer (PS) generated Reactive oxygen singlet. Then, cancer cell suffered irreversible damages. However, PDT had disadvantages such as non-specific targeting feature and poor solubility. To overcome these disadvantages, hydrophilicity and cancer specificity were added to PS. In this study, we synthesized pH responsive polymer with PS (PRPP). In the physiological vessel condition, PRPP is negatively charged, so it was stable. In contrast, the surface charge of PRPP was switched from negative to positive under tumor microenvironment resulting enhanced cell permeability. We confirmed using 1H-NMR, dynamic light scattering, fluorescence spectroscopy. In vitro pH responsive uptake was measured using confocal laser scanning microscopy (CLSM), flow cytometry. Therapeutic potential was confirmed using an MTT assay. |
| 저자 | 임병준1, 정송희1, 박우람2, 이충성1, 나건1 |
| 소속 | 1가톨릭대, 2차의과대 |
| 키워드 | Photodynamic therapy; Reactive oxygen singlet. |
