| 초록 |
Polymeric micelle, the self-assembly of block copolymers with core-shell architecture, is a promising nanocarrier for drug and gene delivery. There are several relevant properties in polymeric micelle as nanocarrier systems, such as longevity in blood circulation, tissue-penetrating ability, spatial and temporal controlled drug release, and reduced inherent toxicity of cytotoxic reagents. Also, engineering of the block copolymer structure allows the preparation of polymeric micelles with integrated smart functions, such as targetability as well as stimuli-sensitivity. This presentation overviews the recent achievements as well as the future perspectives of polymeric micelles as smart nanocarriers for drug and gene delivery. Notable anti-tumor efficacy against hypovascular cancer, including pancreatic cancer and diffused-type stomach cancer, of the polymeric micelles with pH-responding property will be demonstrated to emphasize a promising utility of the nanocarrier-modulated chemotherapy for the treatment of intractable cancers. Gene-loaded polymeric micelles will be shown to be applied as non-viral vectors in the fields of regenerative medicine, particularly bone regeneration, and for the treatment of intractable cardiovascular disease, pulmonary hypertension. Furthermore, the polymeric micelles loaded with imaging as well as therapeutic reagents will be introduced as theranostic nanodevices directing to the new medical paradigm for cancer diagnosis and treatment. |
