| 초록 |
Tissue adhesions are associated with numerous postoperative complications, including patient's pain, functional obstruction, and difficult reoperative surgery. There are many requirements for polymer films or membranes to be used as tissue adhesion barriers. They include the film's flexibility, non-tissue adhesiveness, biodegradability, and nontoxicity of the degraded products in the body. In our previous study, PLLA/PEO diblock copolymers were synthesized by ring-opening polymerization of L-lactide and PEO (mol. wt., 5,000) with different compositions. Tissue adhesion barrier films were prepared from the PLLA/PEO diblock copolymers containing 10 % Ibuprofen as a nonsteroidal anti-inflammatory drug. The drug-containing films prepared by PLLA/PEO copolymers with high PEO compositions were effective for the prevention of tissue cell adhesion on the surfaces, as examined by in vitro cell culture. In this study, Sprague-Dawley rats (weight, ∼ 200 g) were used to evaluate the anti-adhesion potential of the copolymer films (with/without the drug). Rats were received standard surgical defects to their left abdominal wall and cecum, and then the copolymer films were applied to each wound before the abdomen was closed. After 7 and 14 days, their abdomen adhesions were evaluated in terms of PEO composition and absence or presence of drug in the films.
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