| 초록 |
The bimodal distribution of open pore sizes provides a high degree of interconnectivity, high internal surface area, and linearly aligned pores along the walls of the larger pores. It provides a larger surface area and internal volume that is ideal for cell seeding, cell growth, and the production of extra-cellular matrices. Furthermore, the high interconnectivity of the pores allows for distribution of pores throughout the scaffolds, diffusion of nutrients throughout the structure, and the patterning of the surface to guide cell growth. Pore diameter and interconnecting structure are essential to vascularization and tissue ingrowth. The method for preparing functional scaffolds with dual pore system for tissue regeneration comprises the following steps; biodegradable polymers (PLGA and PLLA) were dissolved in a dioxane and water system to prepare a polymeric solution and a nontoxic effervescent salt was mixed homogeneously. The resulting paste was filled into silicone rubber molds and quenched in liquid nitrogen. The amounts of solvents and water crystals were removed by using freeze-drying technique. For gas forming process, polymer-effervescent mixture disks were immersed into 50% of aq. ethanol solution and sonicated at 40℃. After that, the obtained porous scaffolds were rinsed with distilled water and vacuum-dried. These functional scaffolds were evaluated by examining pore size, porosity, mechanical properties, and biodegradability.
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