| 초록 |
The purpose of the present study is to synthesize a zwitterionic copolymers capable of being immobilized on the tooth surface to prevent oral bacterial adhesion. The strategy is to synthesize a zwitterionic copolymers containing Ca2+-binding moieties for strong binding on hydroxyapatite (HA) component of the tooth surface. To this end, a 2-methacryloyloxyethyl phosphate monomer was synthesized and copolymerized with zwitterionic monomers by free radical polymerization. The coating efficiency of the synthesized polymers, with varied composition, onto a HA surface was estimated by means of contact angle measurement and X-ray photoelectron spectroscopy. The anti-biofouling nature of zwitterionic polymer-coated surfaces was estimated by analyzing protein adsorption, cell and S. mutans adhesion. As a result, HA surface coated with a copolymer containing 50% of zwitterionic group showed the best performance in preventing protein adsorption and the downstream cell and bacterial adhesion. |
