| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and characterization of CdSe/ZnS quantum dot encapsulated poly(ethylene glycol)-b-poly(D,L-lactide) micelle nanoparticles |
| 초록 |
The final goal of this study is to develop multi-functional organic/inorganic hybrid nanoparticles, applied for both biomedical imaging probes and drug delivery carriers. As an initial step toward this goal, we used a solid dispersion method for encapsulating CdSe/ZnS quantum dots(QD) into poly(ethylene glycol)-b-poly(D,L-lactide) micelles. The size and morphology of the particles were analyzed by using DLS and AFM. The fluorescence intensity of the particles was determined by fluorescence analysis device. The QD-encapsulated particles had 149±11nm of mean size and 121±12 (RFU) of fluorescence intensity. We also tested the cytotoxicity and cellular uptake of the particles. The cell viability was 60~80% in various concentration ranges of particles. We verified cellular uptake of the particles using a FACS analysis and a confocal microcope. Our results suggest that the QD-encapsulated PEG-PLA nanoparticles can be a promising multi-functional nanocarrier for imaging and drug delivery. |
| 저자 |
이주현1, 임정혁2, 허강무2, 이용규3, 신흥수1
|
| 소속 |
1한양대, 2충남대, 3충주대 |
| 키워드 |
CdSe/ZnS; quantum dots; nanoparticle; PEG-PLA micelle; imaging
|
| E-Mail |
|
