| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Calcium Phosphate Mineralized Self-Assembled Nanoparticles for Enhanced Photodynamic Therapeutic Efficacy |
| 초록 |
Calcium phosphate (CaP) mineralization of self-assembled nanoprticles can produce biocompatible, robust nanocarriers that can induce facilitated drug release in intracellular endo/lysosomes. In this study, we describe the potential of mineralized nanoparticles for photodynamic therapy of tumors. The core-shell-corona polymer micelles (PM) of poly(ethylene glycol)poly(L-aspartic acid)poly(L-phenylalanine) (PEG-PAsp-PPhe) was utilized as a nanotemplate for CaP mineralization. In particular, PAsp middle shells with anionic carboxylates serve as a template for CaP mineralization. The CaP mineral layer of CaP-mineralized PM (PM-CaP) can protect efficiently the release of a photosensitizer (PS) at extracelluar environments (pH 7.4) and dissolve in endosomal compartments (pH 5.0) to facilitate the intracellular release of the PS. In vitro cytotoxicities for breast cancer MCF-7 cells were estimated. Intracellular localization was also confirmed using confocal laser scanning microscopy. |
| 저자 |
이상욱, 이홍재, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
mineralization; nanoparticle; polymeric micelle; photodynamic therapy
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| E-Mail |
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