| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Drug delivery system of anticancer drug using multifunctional polymer |
| 초록 |
In this study, anticancer drug was conjugated to multifunctional polymer (MPD) through acid-cleavable linkage. In addition, target ligand was modified to MPD (TLMPD) for effective cancer therapy. The characterization of TLMPD was confirmed by 1H-NMR, DLS, and HPLC. Evaluation of cell cytotoxicity and antitumor activity was performed by MTT assay. Antitumor activity of TLMPD was higher than that of free anticancer drug. From theses results, we identified that TLMPD could release anticancer drug at endosomal pH due to acid-cleavable linkage. In addition, the uptake efficiency of TLMPD into cancer cell could be enhanced by receptor mediated endocytosis. This research was supported by basic science research program through the national research foundation of korea (NRF) funded by the ministry of education. Science and technology (NRF-2012R1A2A2A01014898). |
| 저자 |
김태훈1, 남정표1, 최창용1, 박성철2, 장미경1, 나재운1
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| 소속 |
1순천대, 2순천대하교 |
| 키워드 |
Multifunctional polymer; 1H-NMR; HPLC; endosomal pH
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| E-Mail |
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