| 초록 |
Multiple drug resistance is a critical barrier in drug delivery system. In this study, we apply photodynamic therapy with chemotherapy using albumin nanoparticles with doxorubicin and microbubbles containing Chlorin e6 (DOX-NPs/Ce6-MBs) to overcome the multiple drug resistance and maximize the therapeutic effect. Microbubbles, which can increase delivery efficiency by cavitation effect, are used as carrier of Chlorin e6. Moreover, reactive oxygen species generated by photodynamic therapy had functional destruction effects on efflux pumps. The therapeutic effects of DOX-NPs/Ce6-MBs were confirmed in adriamycin resistant breast cancer cell. As a result, DOX-NPs/Ce6-MBs improved chemotherapy and photodynamic therapy by efficient delivery of drugs, and the efflux pumps were inhibited by the reactive oxygen species to prevent drug release. We suggest that DOX-NPs/Ce6-MBs with ultrasound and laser can be an efficient platform for cancer therapy by overcoming multiple drug resistance. |
