| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
In-situ Cell Monitoring Upon Exposure to an Anti-cancer Drug in the Functionalized Microfluidic Chip |
| 초록 |
We have fabricated a micro-fluidic biochip which has the surface functionalized cell binding ability and real time monitoring of drug afficacy. For this study, an anticancer drug was encapsulated in the hydrogel beads placed within the micro-channels of the chip. We modified the micro-channel surfaces by layer-by-layer (LbL) deposition with polymers in order to provide efficient cell culturing condition. The LbL coating was locally applied on the areas of the channel which enabled the covninient cellular toxicity monitoting. We also tested the drug afficacy toward cancer cells over normal cells. The results of this study indicate that the micro-channels suitably surface functionalized might be available to effectively monitor cancerous cells upon the exposure to anti-cancer drug in microfluidic chips. |
| 저자 |
김다름, 이수진, 양성윤
|
| 소속 |
충남대 |
| 키워드 |
microfluidic; anti-cancer; in-situ
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| E-Mail |
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