| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
고분자 이론 및 시뮬레이션 |
| 제목 |
Electrostatic bending of intrinsically rigid DNA by binding with a cationic nanoparticle: application to the Brownian motor |
| 초록 |
We design a DNA-based Brownian motor for directional transport of positively charged nanoparticles along a single, long double-stranded DNA (dsDNA) with elaborately designed flexibility variation. To prove its realization, we first investigate the bending of intrinsically rigid dsDNA by binding with a cationic nanoparticle, using the coarse-grained molecular dynamics simulations. An electric charge of the nanoparticle and the sequence-dependent flexibility of dsDNA are varied to elucidate the competitive effects of intrinsic rigidity of dsDNA and electrostatic interactions between charged dsDNA and a nanoparticle. We prove that the nanoparticle wrapped around by dsDNA rolls over the dsDNA towards more flexible region of the dsDNA. This work suggests that dsDNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications. |
| 저자 |
김준수 |
| 소속 |
이화여자대 |
| 키워드 |
DNA flexibility; Brownian motor; electrostatic bending; intrinsic rigidity; coarse-grained molecular dynamics
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| E-Mail |
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