| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Structure-dependent theranostic functions of supramolecular peptide nano-agents |
| 초록 |
Supramolecular theranostic nano-agents were developed by aqueous assembly of peptide building blocks with paramagnetic metal ion-chelated moiety and cancer cell-targeting segment, respectively. Paramagnetic metal-attached scaffolds have attracted much attention as magnetic resonance imaging (MRI) contrast agents (CAs) for diagnostics. Many efforts have been devoted to enhance MRI efficacy of commercial CAs by adopting supramolecular scaffolds to overcome the disadvantages with low sensitivity/specificity. Here, we present the resulting nano-aggregates possess therapeutic effect by delivering hydrophobic anticancer drug model to target cells with regulated MRI-efficacy by morphology control of the nanomaterials. Further, correlation between the morphology of nano-agents and their bioactivities including diagnostic, therapeutic and even antimicrobial activity was elucidated. This study could present a useful approach for developing bespoke clinical nanomaterials with desired activities. |
| 저자 |
김인혜1, 한은희2, 방우영1, 고은희1, 방정규2, 이은지3
|
| 소속 |
1충남대, 2한국기초과학지원(연), 3광주과학기술원 신소재공학부 |
| 키워드 |
self-assembly; peptide nanostructures; theranostics
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| E-Mail |
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