| 학회 |
한국재료학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 광주 김대중컨벤션센터) |
| 권호 |
27권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Demineralized bone matrix and Tri-Calcium Phosphate loaded DBM hydrogel for bone regeneration |
| 초록 |
Decellularized-demineralized bone matrix (DBM), which contains a wide array of growth factors and cytokines, has been used as a bioactive matrix to promote bone regeneration. However, it requires ancillary material for the extensive use of clinical applications. Herein, we presented demineralized bone matrix particles (DBM) and tri-calcium phosphate powder (TCP) loaded DBM hydrogel (hDBM) scaffold for bone regeneration. Microstructures and morphologies of hDBM, DBM loaded hDBM (hDBM/DBM) and DBM and TCP loaded hDBM (hDBM/DBM/TCP) scaffolds were characterized by SEM. In-vitro studies showed that hDBM/DBM/TCP scaffold was biocompatible and could promote osteogenesis by up-regulating the expression of COL-1, OPN, and Runx2 bone-related genes. But unexpectedly, in-vivo studies using the rabbit-femur defect model revealed that the implanted hDBM/DBM/TCP scaffold was shown a similar pattern to fibrous dysplasia while DBM and TCP granule loaded hDBM scaffold (hDBM/DBM/TCPg) showed good bone formation. Loading TCP granules into DBM hydrogel instead of TCP powder was an effective way of modification of DBM hydrogel promoting bone regeneration. |
| 저자 |
Hoe-Jin Kang1, Seong-Su Park2, Byong-Taek Lee3
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| 소속 |
1Institute of Tissue Regeneration, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Decellularized-demineralized bone matrix; tri-calcium phosphate; bone regeneration
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| E-Mail |
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