| 초록 |
Various hydrogel 3D bioprinting technology has been researched with customized designs due to promoted cell adhesion and cell infiltration. Among numerous materials for 3D hydrogel printing, alginate has been widely used in tissue engineering because of its advantages regarding biocompatibility. However, the alginate hydrogel itself exhibits low mechanical properties for use as a bio-ink for 3D printing. In order to improve the mechanical properties of alginate, we introduced SiO2 through the sol-gel method for uniform distribution. Additionally, polydeoxyribonucleotide (PDRN), which is known to have many positive therapeutic effects, was loaded into the alginate/SiO2 bio-ink for further enhancement of biological properties. Based on the results alginate/SiO2 scaffolds, PDRN was incorporated with the optimized condition of alginate/SiO2 bio-ink. Physical properties, release behavior, and biological properties of generated PDRN loaded alginate/SiO2 scaffolds were also assessed. |
