| 초록 |
Titanium (Ti) implants have been widely used due to its biocompatible characteristics for a long time. In this study, we identified Dipterocarpus tuberculatus Roxb. (MED) which is a phenolic mixture of natural plant extract, provided efficient antioxidative and anti-immune activity. Herein, we aim to coat MED on Ti implant and observe how the MED coating influence on osseointegration between the implant and bone tissue. We monitored the change in surface measured by atomic force microscope (AFM), ellipsometry, X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The degree of cell adhesion was compared by scanning electron microscope (SEM) image of attached cells on Ti. Cell viability and various cell adhesion factors were compared. We implanted Ti fixture in rat tibia for 4weeks and observed degree of newly bone formation analyzed by computed tomography (CT) and histological images. |
