| 초록 |
Mesenchymal stem cells (MSCs) can serve as potent carriers to deliver drug-loaded liposomes to tumor microenvironment. Therefore, we designed MSC containing liposomes as cellular carrier system to increase delivery efficiency of doxorubicin (DOX) to tumor microenvironment. At first, we prepared CO2 generated liposome encapsulating DOX. The liposomes were 133 ± 5 nm in size and surface charge was -70 mV, respectively. The loading efficiency of DOX was up to 20 %. Release of DOX from liposomes was 98.2% after NIR irradiation (2 W/cm2, 1 min). The liposomes showed high intracellular uptake into MSCs without cytotoxicity and stayed safe up to 72 hr without drug release from liposome. Additionally, MSCs containing liposomal DOX efficiently migrated in the tumor microenvironment by tumor tropism mechanism. Taken together, this MSCs-based cellular delivery system has potential for targeted tumor therapy with high therapeutic efficacy and low systemic toxicity. |
