| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Structure-dependent magnetic resonance (MR) efficacy of supramolecular theranostic nanomaterials assembled by peptide amphiphiles |
| 초록 |
In this talk, theranostic supramolecular one-dimensional nanoparticles were developed by aqueous assembly of peptide amphiphiles (PAs). Hierarchical nanoplatforms can be tailor-made to suit to the personal needs especially for theranostics by co-assembly of functional PA. Each PA was tagged with tumor-targeting peptide or ligand for paramagnetic metal ion (Gd3+) for magnetic resonance (MR) imaging, respectively. The two types of PA were co-assembled to integrate each PA function into the original 1D nanotemplates. The 1D nano-aggregates allowed successful intracellular delivery of hydrophobic doxorubicin (DOX) to target cells and contrast-enhanced MR imaging by high longitudinal (T1) relaxivity of water protons. Correlation between the structural nature of fibrils formed by co-assembly of PAs and its MR efficacy was elucidated. The performance of nanomaterials could be improved by rational design of chemical structure and the precise control of self-assembly behavior of amphiphiles. |
| 저자 |
김인혜, 류주연, 이은지
|
| 소속 |
충남대 |
| 키워드 |
self-assembly; peptide amphiphile; theranostic; magnetic resonance
|
| E-Mail |
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