| 초록 |
The passive targeting via the enhanced permeability and retention (EPR) effect, has been recognized to facilitate accumulation of nanocarriers in the tumor tissue with leaky vasculature. However, in recent clinical trials, a limit has arisen for successful development due to the poor distribution, leading to a need for strategies to improve EPR. To surmount the limitation, we developed redox-responsive nitric oxide (NO)- generating polymeric micelles for the site-specific delivery of NO, a well-known vasodilating gas. The polymeric micelles, composed of poly(ethylene glycol) and nitrated dextran, are self-assembled owing to the amphiphilic nature and selectively release NO in response to the intracellular reductive environment. The polymeric micelles can not only increase tumor blood flow but also initiate a positive feedback of inviting more micelles into the tumor tissue. This study offers a potential as an alternative for EPR enhancing agents to achieve better therapeutic efficacy. |
