| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of polymeric nanophotosensitizers for photo-triggered immunotherapy of cancer |
| 초록 |
Cancer immunotherapy (IT) is a treatment that activates the body’s immune system to help fight cancer, and photodynamic therapy (PDT) is another cancer treating modality using photosensitizers. Since PDT treatment is known to induce immunogenic responses in the body, a combined therapy of PDT and IT has emerged as a promising cancer treating modality. In this approach, systemic immunogenic responses promoted by topical PDT treatment can provide efficacious treatment of small metastatic tumors as well as primary tumors. Here, we devised a polymeric nano-photosensitizer with encapsulation of a porphyrin derivative for the combined therapy. The phototoxicity and the immunogenic responses during/after PDT treatment using the nano-photosensitizer was evaluated in vitro on melanoma cells and in vivo on a mouse model of melanoma. Finally, we demonstrated that the combined therapy using the nano-photosensitizer is indeed operative for the efficacious cancer treatment. |
| 저자 |
이서경1, 정근수1, 박성준1, 박재형2, 김세훈1
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| 소속 |
1한국과학기술(연), 2성균관대 |
| 키워드 |
immunotherapy; photodynamic therapy; nano-photosensitizer
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| E-Mail |
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