| 초록 |
Overproduction of hydrogen peroxide(H2O2), one of the main reactive oxygen species, is involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis. Herein, we prepared hybrid nanoparticles(HNPs), consisting of a luminol derivative(L012) and quantum dots(QDs) and demonstrated their potential as the chemiluminescent agents for in vivo optical imaging of H2O2. Since L012 produces energy by specific reaction with H2O2, we hypothesized that QDs in HNPs can emit near infrared(NIR) light via chemiluminescence resonance energy transfer(CRET). In the presence of H2O2, no significant NIR signals were detected from L012 and QDs, whereas strong signals were observed in HNPs inferring that L012 and QD in HNPs served as the CRET donor and acceptor, respectively. Furthermore, the HNPs enabled in vivo imaging of H2O2 in animal models with prostate cancer, acute inflammation and rheumatoid arthritis. Overall, HNPs might be promising diagnostic agent for H2O2-associated diseases. |
