| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Biodistribution of Hyaluronic Acid-Based Nanoparticles |
| 초록 |
Biodistribution of hyaluronic acid (HA) nanoparticles were investigated using the near infrared (NIR)-based optical imaging technique. Cy5.5, a NIR dye, was chemically conjugated into the HA nanoparticles to visualize their biodistribution in the tumor-bearing mice. The nanoparticles were injected intravenously into athymic nude mice bearing subcutaneous SCC-7 tumors. The images showed that Cy5.5-labeled HA nanoparticles were specifically accumulated at the tumor site and liver because of the receptors such as CD44 on tumor cells and the HA receptor on liver endothelial cells. In conclusion, it was demonstrated that Cy5.5-labeled HA nanoparticle probes can be accumulated at specific site such as tumor and liver. |
| 저자 |
최기영1, 이슬기2, 박경순2, 김광명2, 박재형1, 권익찬2, 정서영1
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| 소속 |
1경희대, 2한국과학기술(연) |
| 키워드 |
hyaluronic acid; nanoparticle; molecular imaging
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| E-Mail |
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