| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Application of Chitosan-graft-Cationic Polymer as a Gene Carrier |
| 초록 |
To generate a good gene transfection carrier, chitosan-graft-cationic agent (OCP) copolymers were synthesized by coupling reaction with increasing weight percentage of cationic polymer. The physicochemical character of OCP was investigated by 1H-NMR. The particle size distribution of the OCP/pDNA nanoparticles was determined by the dynamic light scattering (DLS) technique. We confirmed the gene expression level of OCP/pDNA complexes by the Luciferase assays in various cancer cell lines and normal cell line. The results demonstrated that the prepared OCP copolymer in this study is a promising carrier for in vitro and in vivo gene delivery applications. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded the Ministry of Education, Science and Technology (NRF-2011-0012039). |
| 저자 |
김영민1, 장재영1, 김준호1, 박준규1, 남정표1, 박성철1, 최창용2, 박영훈1, 나재운1, 장미경1
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| 소속 |
1순천대, 2다이나믹 |
| 키워드 |
chitosan; GDS; gene delivery; pDNA
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| E-Mail |
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