| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
A pH-sensitive drug release for doxorubicin delivery |
| 초록 |
Doxorubicin (DOX)-conjugated dimethylmaleic anhydride was synthesized for pH- sensitive drug release. To improve a targeting drug delivery system, an water soluble chitosan (WSC) was conjugated with DOX and folic acid (FA) (FAWSCDOX). FAWSCDOX of chemical structure was investigated by 1H-NMR and FT-IR. The particle size distribution was investigated by DLS. In addition, the antitumor activity of FAWSCDOX was evaluated against HeLa cell by MTT assay. The result suggested that FAWSCDOX might be a promised anticancer drug carrier for cancer therapy. This research was supported by basic science research program through the national research foundation of korea (NRF) funded by the ministry of education. Science and technology (NRF-2012R1A2A2A01014898). |
| 저자 |
김태훈, 정경원, 손동희, 남정표, 최창용, 박성철, 박영훈, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
pH-sensitive; doxorubicin; folic acid; folic acid receptor
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| E-Mail |
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