| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The Effect of Bone Differentiation of Chondrocyte in PLGA/Hydroxyaptite/Silk Scaffolds |
| 초록 |
Bone is a highly complex tissue which provides mechanical support, and acts as mineral reservoir. We used Poly(lactic-co-glycolic acid)(PLGA) with good biocompatibility and the silk as a natural biomaterial. However, as silk is not an osteogenic material, hydroxyapatite (HAp) with osteoconductive property was added. In the study, PLGA scaffold as a control group, 10 wt% HAp/PLGA, 10 wt% Silk/PLGA, 5 wt% HAp/5 wt% Silk /PLGA (5 wt% H/S/P) and 10 wt% HAp/10 wt% Silk/PLGA (10 wt% H/S/P) scaffolds as experiment groups were prepared. We executed the MTT assay and SEM observation. Also, the degree of differentiation of bone by ALP assay and RT-PCR were analyzed. The analysis of ALP and the result of RT-PCR showed that 10 wt% H/S/P scaffold was significantly increased over time. These results suggest that 10 wt% H/S/P scaffold should serve as structural bases for bone tissue engineering. This research was supported by NIFAFF (112007-05-1-SB010) and (MEST) (2012M3A9C6050204). |
| 저자 |
박상미, 김혜윤, 김영래, 김형석, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
PLGA; HAp; Silk; Bone regeneration
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| E-Mail |
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