| 초록 |
Drug delivery system including nanoparticles are under active developmentbut most of the nanoparticles enter the cell via endocytosis. However, asignificant amount of the endocytosed cargos is degraded due to endosomalentrapment and lysosomal degradation. Thus, in recent years, several attemptshave been made to develop transmembrane delivery systems such as cellpenetrating peptide (CPP)-conjugated nanoparticles rather than endocytosis.However, CPP is known to be degraded and inactivated by serum proteases in invivo. To overcome the limitations, we have developed phospholipid-basednanodrill nanoparticle (LD-NPs) via self-assembly of phospholipids. LD-NPspenetrate the cells via energy-independent penetration through the membrane,unlike other nanoparticles. The potential of LD-NPs in drug delivery wasconfirmed through in vitro and in vivo experiments, such as gene therapy,chemotherapy to drug resistance cells and enhanced local drug delivery to the brain. |
