| 학회 | 한국화학공학회 |
| 학술대회 | 2004년 봄 (04/23 ~ 04/24, 공주대학교) |
| 권호 | 10권 1호, p.304 |
| 발표분야 | 분리기술 |
| 제목 | Formation of PHB micro particles using supercritical carbon dioxide |
| 초록 | Application of supercritical fluids, especially with supercritical CO2 for processing of pharmaceuticals and sustainable plastic has been attracted considerable interests in recent years. A variety of the Supercritical Anti-Solvent (SAS) process is the Aerosol Solvent Extraction System (ASES), in which a drug or polymer solution is sprayed into a high pressure chamber flowing supercritical fluid. Some of the most studies have involved the use of supercritical fluids technology for the micronizing biodegradable polymers such as Poly(3-hydroxybutyric acid) (PHB), L-polylactic acid (L-PLA) and so on . All of which have been used extensively in medical and pharmaceutical applications including materials for tissue engineering and drug carriers. The experiments were performed by changing variables such as pressure (75-200bar), temperature (31-60ºC), initial concentration (0.3-4.0wt%) and solution flow rate (0.3-2.3ml/min). The particle size and morphology were measured using Scanning Electron Microscopy (SEM) and Particle Size Analyzer (PSA). In all cases of ASES experiments, it can be obtained non-agglomerated and spherical fine particles with smooth surface. |
| 저자 | 정헌섭1, 이창하2, 김재덕1, 임종성3, 이윤우4 |
| 소속 | 1한국과학기술(연), 2연세대, 3서강대, 4서울대 |
| 키워드 | Supercritical CO2; Biodegradable polymer; Poly(3-hydroxybutyric acid) (PHB); Aerosol solvent extraction system |
| 원문파일 | 초록 보기 |
