| 초록 |
Hyaluronic acid (HA) is a naturally-occurring polysaccharide with excellent biocompatibility, viscoelasticity, biodegradability, and hygroscopic properties. Here, we developed poly(allylamine), PAAm modified upconversion nanoparticle / HA - rose bengal (UCNP/PAAm/HA-RB) conjugate complex for photochemical tissue bonding with near-infrared (NIR) light illumination. Compared to the conventional invasive treatment via suturing and stapling, UCNP/PAAm/HA-RB conjugate complex could be non-invasively delivered into the deep tissue and accelerate the tissue bonding upon NIR light illumination. In addition, we developed in situ supramolecularly assembled and modularly modified HA hydrogels for genetically engineered mesenchymal stem cell (eMSC) therapy. The long-term expression of mutant interleukin-12 by eMSCs within the supramolecular HA hydrogels resulted in effective inhibition of tumor growth with a significantly enhanced survival rate. |
