| 초록 |
Ultrasound imaging is one of the most commonly employed diagnostic modalities with CT, MRI and PET in clinics. Among them, ultrasound imaging allows accurate ultrasound imaging of organs in various diseases of cancerous lesions, inflammatory responses and cardiovascular pathologies with the assistance of contrast agents. However, microbubbles have several limitations for sensitive and specific molecular imaging. To overcome these limitations, there has been increasing interest in the development of pathological stimulus-activatable nanoplatforms with theranostic functions as an alternative to gas-filled microbubbles for contrast-enhanced ultrasound imaging. In this work, we developed acid-triggered bubble generating polymer nanoparticels for ultrasound imaging and targeted drug delivery using ketalized maltodextrin (KMD). We anticipate that KMD nanoparticles could serve as ultrasound imaging agents as well as drug carriers for various inflammatory diseases. |
