| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
분자전자 부문위원회 I |
| 제목 |
Red-Fluorescent Organic J-type Nanoparticles Capable of Fluorescence Detection of Amyloid-β Aggregates |
| 초록 |
Monitoring the amyloid-β (Aβ) aggregation processes can enable early diagnosis and treatments of neurodegenerative diseases. We synthesized a series of donor-acceptor-donor molecules (SN1-5), and employed their fluorescent molecular assemblies for detection of Aβ aggregation. Among the SN compounds, SN1 and SN2 self-assembled into J-assemblies which showed strong and red-emissive nanoparticles in buffered solutions. X-ray crystal structure analyses revealed a 15.2° slip angle of the transition dipole moment along the intermolecular J-axis. Upon the addition of Aβ species, SN2 produced fluorescence ratiometric responses. Mechanistic studies indicated that the fluorescence responses could be ascribed to hydrophobic interactions with Aβ aggregates at the surface of the probe assemblies. |
| 저자 |
김소남, 유영민
|
| 소속 |
이화여자대 |
| 키워드 |
Amyloid-beta; fluorescence; probe; J-type assembly
|
| E-Mail |
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