| 학회 |
한국화학공학회 |
| 학술대회 |
2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 |
28권 1호, p.936 |
| 발표분야 |
[주제 10] 헬스케어 |
| 제목 |
Micropore Device for Decoding 4-bit Hydrogel Barcode |
| 초록 |
Encoded hydrogel microparticles have shown great potential for biomolecule assays for their multiplex capability and solution-phase reaction kinetics. However, the methods currently used for recognizing assigned codes on the particles and their binding states are very slow or require a complicated system. In this work, we report the precise decoding of a shape-modulated hydrogel barcode particle using a micropore fluidic device. Using an electrical simulation, we deduced the optimal pore geometry that yields the maximal sensing signal. We fabricated hydrogel particles with different dimensions and prepared the micropore device along with a fluidic cell and a patch clamp. Accordingly, we experimentally determined the most appropriate shape of the hydrogel barcode particle that allows efficient differentiation between a 0 code and a 1 code. Thus, we successfully decoded 4-bit hydrogel barcode particles with high speed and high accuracy. |
| 저자 |
배수현, 류지헌, 김현웅, 송창우, 신세현, 한창수, 봉기완
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| 소속 |
고려대 |
| 키워드 |
이동현상(Transport Phenomena) |
| E-Mail |
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| 원문파일 |
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