| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vitro Permeation Behavior of 5-FU Hydrogel |
| 초록 |
5-Fluorouracil (5-FU) has been widely used to treat cancer as types of i.v. and oral adminstration. However, it induces many side effects and has short half-life time of 10-20 minutes. Furthermore, it has low bioavailability of 20 % due to the hepatic first pass effect. Therefore, we developed novel TDDS using hydrogel and microneedle system. 5, 8 and 10 w/v% of Carbopol 940NF was added in hydrogel containing 5-FU to improve permeability. Viscosity of hydrogel increased with increase of Carbopol contents. We applied these novel DDS to hairless mice skin treated and untreated with microneedle system and evaluated drug permeability into skin. The hydrogel containing 8 w/v% Carbopol showed best permeability among three groups. We concluded viscosity of drug acts important factor in permeability into skin and bioavailability could be improved through our novel TDDS. |
| 저자 |
안식일, 박종학, 이준희, 김윤태, 김대성, 김원, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
5-Fluorouracil; Hydrogel; Microneedle; Viscosity
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| E-Mail |
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