| 초록 |
Although cancer immunotherapy has been established as a new pillar of standard cancer treatment, critical issues still remain including low response rate to the immune-resistant “cold” tumors. To address the limitation, I have developed effective immunoengineering strategies using biomaterials and nanotechnology that can efficiently eradicate “cold” tumors, amplify tumor-specific immune responses, and sensitize tumors to immunotherapies. In particular, I have developed spiky gold nanoparticles as a new efficient photothermal agent and demonstrated that photothermal therapy can elicit robust anti-tumor immunity against primary as well as disseminated tumors in combination with chemotherapy or cancer vaccine. In addition, I have developed modularly programmable polyethyleneimine‐based nanoparticles for neoantigen cancer vaccine and combination nano-immunotherapy. |
