| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
고분자구조 및 물성 |
| 제목 |
DNA-Mimic Brush Polymers Bearing Adenine Moieties: Layer-by-Layer Self-Assembly and Biocompatibility |
| 초록 |
Well-defined DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)-ethylene] (PECH-AS). Both brush polymers formed molecular multibilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. |
| 저자 |
위동우, 김진철, 정정운, 노예철, 김미희, 권원상, 안병철, 김경태, 정성민, 고용기, 권경호, 김영용, 김종현, 송성진, 이진석, 이문호
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| 소속 |
포항공과대 |
| 키워드 |
brush polymer; adenine; self-assembly; biocompatibilityz
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| E-Mail |
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