| 초록 |
Diabetes is one of the most severe disease worldwide. So it is important to check the blood glucose level daily. Electrochemical glucose biosensor based on glucose oxidase (GOx) draws attention, since it is possible to use at home. However, this biosensor has still low performance and need the mediator. Here, conductive m-CeO2/C anchoring the GOx was synthesized for the efficient electrochemical biosensor. m-CeO2/C was prepared by the co-assembly of cerium nitrate, resol, and triblock copolymer via an EISA. m-CeO2/C enhanced the biosensor performance, since mesoporous carbon matrix has high conductivity and low background current. In addition, due to its large surface area and pore volume, m-CeO2/C could load much higher amount of biomolecules. Most of all, CeO2 could act as a redox couple, the biosensor did not need additional mediator. H2O2 generated by catalytic reaction of GOx was converted into hydroxyl radical through catalytic activity of CeO2, which induced the anodic current due to the anodic oxidation of Ce3+. m-CeO2/C showed higher resolution, and linear current response for target glucose, which is proper to measure the serum glucose. |
