| 초록 |
A biocompatible and tumor-targetable near infrared (NIR)-responsive tungsten oxide (WO3) nanoparticle was designed via surface functionalization with dopamine-conjugated hyaluronic acid. The functionalized nanoparticles (HA@WO3) provided targeted photothermal heat under NIR irradiation in MDAMB and A549 cancer cells and triggering in vitro photothermolysis of cancer cells, which this phenomenon did not occur in normal MDCK cell, indicating good selectivity of HA@WO3 towards a cancer cell. Furthermore, in vivo experiment revealed that HA@WO3 demonstrated an efficient photothermal conversion with long time accumulation in targeted tumor as a result of the biocompatibility of HA@WO3. Thus, this functionalized nanoparticle is promising and potential as anticancer agent which is biocompatible, sensitive, selective, and effective for photothermal-based cancer therapy. |
