| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.182 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Self-Emulsifying Drug Delivery System for Piroxicam ;In Vitro Transdermal Release and Permeation Studies |
| 초록 | The aim of the present work was to compare a self-emulsifying drug delivery system (SEDDS) with sample to predict transdermal efficiency of a series of nonsteroidal anti-inflammatory drugs (NSAIDs) : piroxicam, which has been well absorbed following oral administration. However its use has been associated with a number of undesirable side effects on the stomach, nausea, etc.. We have produced SEDDS containing piroxicam with various oils and surfactants. The permeation studies were carried out Keshary-Chien diffusion cells across hairless mouse skin and high performance liquid chromatography (HPLC) analysis.In vitro, the transdermal penetration profile of piroxicam SEDDS was showed difference with the droplet size, oil and surfactant by the investigation of the emulsion formation. This result suggests a possible use of the patch as a transdermal delivery system of SEDDS. Acknowledgement: This work was supported by KMOHW (Grant No.; HMP-98-G-2-051-B). |
| 저자 | 윤복영1, 서선아*2, 강복기*3, 정상영**, 강길선, 이해방**, 조선행** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연) |
| 키워드 | piroxicam; self-emulsion; <i>in vitro</i>; transdermal |
