| 초록 |
Overproduction of hydrogen peroxide (H2O2) has been commonly implicated in various inflammatory diseases and therefore holds tremendous potential as a diagnostic and therapeutic biomarker for inflammatory diseases. In this regard, we developed poly(vanillyl alcohol-co-oxalate) (PVAX), which rapidly scavenges H2O2 and exerts antioxidant and anti-inflammatory activity. The therapeutic potential of PVAX nanoparticles was studied using a number of mouse models such as ischemia/reperfusion, airway inflammation, acute liver failure and contusion injury. Based on the hypothesis that H2O2-mediated hydrolysis of PVAX nanoparticles generates CO2 bubbles, we also studied the potential of PVAX nanoparticles as a H2O2-activatable ultrasound contrast agent and therapeutic agent for musculoskeletal injuries. Upon intramuscular injection, PVAX nanoparticles significantly enhanced the ultrasound contrast and inhibited contusion-mediated inflammation and apoptosis in the musculoskeletal system. |
