| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | NovelIonizable Lipids for in vivo Delivery of mRNA therapeutics |
| 초록 | Lipid nanoparticles(LNP) formulations based on ionizable lipids have shown great promise for the invivo delivery of RNA therapeutics. Their delivery efficacy has been wellverified, however, challenges associated with cellular and immune toxicitystill remain. To overcome these limitations, we aim to develop new class ofionizable lipids with low cellular toxicity. By incorporating biodegradable bondswithin the lipid structures, they can be easily removed from the cellularenvironment to maintain normal homeostasis. With newly synthesized ionizablelipids, we have performed comparative analysis of these materials in vitro and in vivo. These results demonstrate that the biodegradable LNPs havea comparative gene-silencing activity as compared to the non-degradable LNPswhile lowering the toxicity issues. |
| 저자 | JEONG MICHAELA, 이혁진, 김민정 |
| 소속 | 이화여자대 |
| 키워드 | lipid nanoparticles; mRNA; RNA therapeutics |
