| 초록 |
Nitric oxide (NO) has been known to have potential as a chemosensitizing agent for cancer chemotherapy. Recently, mineralized nanoparticles have shown efficient loading potential and delivery ability of therapeutic agents. Herein, we aim to develop a NONOates-loaded mineralized nanoparticle (NONOates-MNP) which can deliver NO intracellularly and act as a chemosensitizer to improve therapeutic efficacy for doxorubicin (DOX). The NONOates-MNP was prepared by CaCO3 mineralization using NONOates-loaded poly(ethylene glycol-b-polyethyleneimine) (PEG-b-PEI) block copolymer as templates. CaCO3 core phase of the MNP would effectively protect NONOates at physiological pH. However, at acidic pH of endosome, NONOates would be exposed to an aqueous environment as CaCO3 core phase degrades and release NO molecules at the cytoplasm. We demonstrated that NO produced intracellularly sensitized the MCF-7 cells to DOX, thereby augmenting anticancer activity of DOX. |
