| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-무기재료 |
| 제목 | Peroxidase mimicking nanozyme in neutral pHfor paper sensor with direct cascade reaction |
| 초록 | The development of Co-doped mesoporouscerium oxide (Co-m-ceria) is described here, which functions best atnear-neutral pH and has a 600-fold better peroxidase-like catalytic efficiencythan m-ceria. To choose Co as the optimal dopant, DFT simulations for the useof various metal-doped m-ceria in peroxidase-like reactions under various pHconditions were performed. Because of Co-m-strong ceria's peroxidase-likeactivity under neutral pH and its mesoporous structure, it may be used in aone-pot cascade reaction system to detect biomarkers of oxidative enzymeswithout changing the pH. Five separate oxidative enzymes are immobilized athigh loadings in the pores of Co-m-ceria, then the enzyme-containing Co-m-ceriais incorporated into paper microfluidic devices for the easy and simultaneousdetection of several biomarkers. Using a smartphone-acquired image, the Co-m-ceria-incorporatedpaper microfluidic device allows for the selective and sensitive determinationof multiple biomarkers. |
| 저자 | 이준상, 이진우 |
| 소속 | 한국과학기술원 |
| 키워드 | 나노자임 |
