| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Ph-ResponsiveDrug Delivery of the Calcium Phosphate Nanoparticles Based on ProteinConjugated with Tumor Targeting Peptide |
| 초록 | Calcium phosphate has high biodegradability due to its chemicalsimilar to human hard tissue, and endosomal escape through the action of saltsis possible, thereby minimizing drug damage. A conjugate of Bovine SerumAlbumin(BSA), a protein, a tumor targeting peptide(Gly-Gly-Arg-Arg-Glu; GGRRE),and doxorubicin, an anticancer drug, was formed to construct an anticancer drugdelivery system together with calcium phosphate. As a result of analyzing thedifference in nanoparticle structure according to pH, the shape became largerand irregularly changed at a low pH of about pH 5.0. As these nanoparticlerespond to pH, the drug can act as quickly as possible because the structureloosens, osmotic pressure increases, and endosome destruction occurssequentially. It showed clear cytotoxicity in tumor cells overexpressing thecathepsin B enzyme, while less toxicity in normal cells with little cathepsin Bexpression. |
| 저자 | 박의창, 허윤석, 김은수, 김수헌, 이후민, 김관우 |
| 소속 | 인하대 |
| 키워드 | Anticancer; Nanoparticle; Chemotherapy; Peptide |
