| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-콜로이드·계면화학 |
| 제목 | Protein delivery of poly(amino acid)’s derivatives with β-sheet structure |
| 초록 | Nano-sized self-assemblies formed with amphiphilic graft copolymers have been extensively studied for drug delivery including transdermal drug delivery system. This study reports a novel strategy to prepare biomimetic self-assemblies by varying packing of β-sheet which are secondary structures. Specifically, the amphiphilic graft copolymers, PHEA-g-oligo(L-valine)composed of poly(amino acid)s derivative and oligo(L-valine) which to form β-sheet as the grafted hydrophobic chain were successfully synthesized. The self-assembly ratio of β-sheet formed in PHEA-g-oligo was simulated equal to the secondary structure content of EGF, and its contents were 28.5 %. Finally, EGF was introduced with PHEA-g-oligo and applied to cosmeceuticals to efficiently deliver EGF to the human skin. This strategy would applicable to prepare cosmeceutical system. |
| 저자 | 한사라, 지윤숙, 정재현 |
| 소속 | 숭실대 |
| 키워드 | self-assembly; secondary structures; oligo(L-valine); degree of substitution; protein delivery; epidermal growth factor |
