| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
In vitro and In vivo Applications of the biofunctional stents with endothelial progenitor cell specificity for vascular re-endothelialization |
| 초록 |
Endothelial progenitor cells (EPCs) are important in the field of stent research due to its re-endothelialization effect, which can prevent stent thrombosis and neointimal hyperplasia. To fabricate the EPCs-capturing stent of excellent performance, a highly biocompatible surface modification technology is indispensable. In this study, we fabricated a biofunctional stent which can capture EPC specifically. The stent was prepared through grafting a hydrophilic polymer and immobilizing the antibody against vascular endothelial cadherin (VE-cadherin), which is one of the specific EPC surface markers. The anti-VE-cadherin antibody-immobilized stent captured the EPCs effectively, whereas THP-1s, human acute monocytic leukemia cells, were not adsorbed on the stent. Furthermore, we confirmed that the captured EPCs nicely developed the endothelial cell layers on the antibody-conjugated stent through in vitro and in vivo experiments. |
| 저자 |
경산1, 강찬구2, 임우현1, 이주명1, 이윤식1
|
| 소속 |
1서울대, 2삼성경제(연) |
| 키워드 |
Stent; Polymer Grafting; Endothelial Progenitor Cell
|
| E-Mail |
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